That's a great question. And it's one that we've actually discussed with Dr. Michael Hamblin of Harvard University and in fact that's his favorite thing to do with photobiomodulation or light therapy is actually treat his brain. The theory there is because of the specific wavelengths of light are able to help restore healthy cellular and more importantly near infrared is capable of penetrating through muscle and even bone tissue to reach the brain and so it's actually quite effective for a number of brain function benefits.
At a high level, specific wavelengths of light are helping our mitochondria produce more ATP. And if you want to peel back the layers of the onion a little bit, most photo medicine researchers, although the field is still relatively new, most scientists that study this on a daily basis really hone in on the fourth phase of cellular respirations
During that fourth phase of cellular respiration, the goal of our mitochondria is to create this gradient, this energy gradient, through the electron transport chain. We get basically two sides of the ETC as it's often referred to as where one side has a very negative charge, the other side has a positive charge. What happens when our cells aren't functioning properly, you don't get this gradient. This gradient becomes just not as much of a significant difference in the charges. So one enzyme in particular nitric oxide when our cells produce too much of it, it has a tendency to bind a certain protein enzymes that transfer across this gradient and so electrons aren't spinning off.
So specific wavelengths of light is just to mention typically in the low to mid 800 nanometer range, the near infrared IRA range and then in the low it's 600 nanometer range. There's enzymes that have sort of an affinity to use this photons of light. Cytochrome c oxidase is one of those enzymes. So these specific wavelengths of light help actually to break those bonds that nitric oxide creates with certain enzymes like cytochrome c oxidase helping your cells spit off more electrons that then create this gradient where then you can produce more ADP which is then converted into ATP or cellular energy. So that's actually sort of what's happening at a biochemical level when it comes to light therapy and the end goal of producing more ATP.
Dave Asprey A lot of people listening have heard me talk about nitric oxide and those people with beetroot products to increase nitric oxide. But there's a little bit of biochemistry that I think is worth talking about. It turns out there's three kinds of nitric oxide that your body has. There's neural nitric oxide uses in the brain, there's endothelial in the circulation system which is the one that we're always looking for and basically better erections, better blood flow. Everywhere in the body that blood needs to flow. Then there's also one called inducible and this is the one that's relatively toxic and there is actually three different genes you can have called NOS1, NOS2 and NOS3 that help your body know how much of which one you're likely to produce.
And when you get inflammation you get too much inducible nitric oxide or nitric oxide synthase actually. And what happens with that then is you get inflammation because it turns to peroxynitrite in the cells which creates free radicals and you have to have really strong mitochondria to turn off the free radicals and you basically get jacked up. So for some of us taking lots of nitric oxide, things like arginine, is actually going to trigger inflammation and for the rest of us it's going to trigger a better day or better brain.
Justin Strahan: That's one of the first things that we looked at because low level laser therapy or LLLT also called cold laser therapy has been around for decades and has been proven to be quite effective for different types of recovery. Physical therapists, you bang up your knee or you're recovering after a surgery, it's been proven for some time. But really what's relatively new is the aspect of being able to do the same thing with LEDs. And that was really proven by a handful of studies in the 90s, it basically demonstrated that basically the important factor was the wavelength and the intensity of the light. So essentially your cells don't care what technology created the photons that they're being bombarded with, they basically just care about the intensity and the wavelength.
Dave Asprey: This thing I used had a treatment area about the the size of maybe two one dollar coins. It was relatively small and I run about five grand. I ended up meeting the guy who created this and he was this older dentist who invented the first dental laser sometime in the 70s or something. And he had the most perfect set of teeth I had ever seen and he was talking all about jaw alignment and he'd invented this light specifically with laser, specifically to affect the trigeminal nerve. If people listening are interested in jaw alignment, TMJ or sleep apnea, I interviewed Dwight Jennings who is a jaw alignment specialist. So I realigned my jaw that totally changed my nervous system which was really kind of cool. And the whole time I'm using this red and infrared laser on my jaw to chill out all the inflammation that's driven in the trigeminal nerve, which if it's inflamed it will inflame the vagus nerve which controls a lot of stuff throughout the body, including fight or flight response
Scott Nelson: And just to add that. The gold standard within the photobiomodulation community is continuous wave therapy. Across the board you talk to any photo medicine researcher they'll say by far and away continuous wave, there's so much evidence that supports that. In fact there's over 200 double blind placebo control studies on continuous wave light therapy but
Scott Nelson: I think you're spot on. Most people would say there's kind of two aspects to pulsing. One would be the ability to generate more power in a relatively short amount of time without risk of overheating. So you can actually deliver that energy deeper into tissue because most people that say every centimeter you're losing about 90% of the energy. That's one aspect. But the other aspect that's a little bit more unknown is what you just hit on Dave is that at a mitochondrial level, what is that frequency? How are ourselves, our mitochondria specifically responding in terms of the residence of that frequency.
Tyler LeBaron 482 Hacking with Hydrogen
Actually, I came across an article published in Nature Medicine in 2007, which showed that hydrogen was therapeutic and you could suppress brain damage, and I was, "Wow, this is very interesting." Ever since, 2009, I read all the articles, and then had the opportunity to go to Japan and actually do research. Since then I have continued my research and collaboration with universities and different groups, institutes, all throughout the world, and throughout China, and Europe, and then elsewhere.
. A number of the clinical trials very positive effects, but just going back to this idea from the standpoint that hydrogen, the first element in existence, right, this neutral diatomic gas that is so prevalent, and is so simple, and is essentially biologically inert, would have a therapeutic effect. It's strange.
First we can talk about say the antiinflammatory effects. In order to understand this, we need to talk a little bit about what causes inflammation, and inflammation can be caused from various pro-inflammatory mediators, such as pro-inflammatory cytokines, those like interleukin 6, interleukin 2, interleukin 12
Hydrogen really shines in its ability to bring back the inflammation to homeostasis, so it can help to dow regular these pro-inflammatory mediators that are excessive and bring them back into the normal range.
Perhaps in other cases, in the initial stage it can actually increase or enhance the proinflammatory mediators. We've seen this from several studies. For example, hydrogen can indirectly activate NF-κB, which is a transcription factor. When NF-κB binds to the DNA in the nucleus, then NF-κB induces the transcription of various cytokines. Well, some of these studies have shown that hydrogen can, in the initial stage, actually activate NF-κB, and then you have a slight mild transient increase in inflammation followed by a decrease in inflammation that is systemic, and now you have improved benefits for many of these various diseases that we're talking about.
Well, there was a study published in 2012, and some other ones in 2013 and 2014 where they showed in a double-blinded, placebo-controlled, randomized fashion that the ingestion of hydrogenrich water was very significant at improving the symptoms of rheumatoid arthritis, and decreasing the markers of oxidative stress, like OHdG, which is a marker of DNA damage, insomuch that some of the patients with early-stage rheumatoid arthritis they actually had a complete remission of the disease. Their markers of the acetylated proteins, for example, that are markers of the rheumatoid arthritis disease, were back to a normal level, as though they did not have the disease anymore
This was also found by Dr. Noda, also one of our advisors. She found and published, actually in 2009, as she induced a Parkinson's disease in an animal model using a toxin, 6- hydroxydopamine, and the benefits of the hydrogen are very clear. Ingestion of hydrogen-rich water completely prevented the development of Parkinson's disease in this animal model, and this was a powerful article. She's a great researcher at Kyushu University. She used to research at Rockefeller University, for example.
Well, there's a number of ways to do it. There's quite a few ways. In fact, one of the first ways was done using hyperbaric hydrogen therapy. Of course, we're familiar with the hyperbaric oxygen, but you could do the same with a hyperbaric hydrogen
Hydrogen as a signal modulator alters gene expression, and it takes time to induce like PGC-1alpha, and a number of different changes, and those small changes over time lead to very significant improvements
one of the most harmful free radicals is called peroxynitrite, and this forms inside your cells, inside your mitochondria, as you're turning food and air into electrons to use in the body.
. It's the smallest molecule. It's smaller than oxygen is, and it's able to selectively reduce, or decrease, those levels. It's likely not done via direct radical scavenging. In other words, it may not be through a direct reaction if you look at the rate constants of the hydrogen gas and hydroxy radicals, but its selective reduction of those radicals is very critical, and that was shown in the 2007 Nature Medicine publication, that hydrogen was selective in its ability to simply only decrease those types of ROS, Reactive Oxygen Species, and not the other ones. Nitric oxide, that is a free radical. That's how the Viagra works. It's all these things that you mentioned earlier. We don't want to neutralize that. A superoxide anion radical, hydrogen peroxide, these are all very important assimilating molecules and, in fact, when we exercise we increase our levels of these Reactive Oxygen Species, and these Reactive Oxygen Species and these Reactive Oxygen Species are, in turn, what mediate a lot of the benefits of exercise training. They are what induce mitochondrial biogenesis, and increase vascularization. Some various reports have shown that ingestion of high levels of exogenous antioxidants can actually negate the benefits of exercise training and, perhaps, some of that is due to the scavenging or neutralization of these critical stimulating molecules.
When it comes to hydrogen, it doesn't do that. It's only going to bring things back to that homeostasis that we need. In fact, in some cases, hydrogen can act as a prooxidant. One article published recently showed that ACE2 acts as a mito hormetic effector. In other words, mito meaning mitochondria, and it actually showed that it transly increased superoxide production in the mitochondria, as measured through mitoSOX. I guess we don't need to go into all that, but it [transly 00:27:40] increased the superoxide production, just initially, and a little bit of hydrogen peroxide, and then you quickly saw an up regulation of the Nrf2 pathway, which is a transcription factor that you get hig
You can buy the H2 blue, which is a redox titration reagent, and from h2sciencesinc.com.
Exactly. It's a titration reagent. It's methylene blue with some colloidal platinum as a catalyst, and it will actually, you can use it to measure the concentration of hydrogen.
Dave: Very cool. I don't know that I'm a position to recommend, you know, go out and buy something right now. I can tell you that breathing the gas seems to work from, the name of the inhaler, it's like MiZ,
those with the genotype APOE4, and those genotype APOE4 are more susceptible to Alzheimer's disease. In fact, about 50% of everybody who has Alzheimer's disease have that genotype or are a carrier
Dan Levendowski 520
For example on neurodegeneration or being able to phenotype, phenotype is where you have a very distinctive characteristic. We're beginning to phenotype insomnia, for example, to identify what type of patients who have insomnia that may be better taking hypnotic medications, and which would be better for other types of therapy as a treatment.
. When you discuss sleep, there's really two aspects. One is what they call architecture, and that's where many of your listeners may be aware of, they have lighter sleep, and deeper sleep, and rapid eye movement sleep. We have a total of four stages of sleep. Then there's sleep continuity, and that's the part where if your sleep is getting interrupted or fragmented, then you don't get as much continuous sleep
Slow wave sleep is very, very important. You're better off having an hour of slow wave sleep
Well, it's a Sleep Profiler, is the product that we've developed for this purpose
One thing you can do with the clinical grade data is you can put on your Oura ring or whatever else that you're using, that is, we'll call it simpler, less sophisticated, and you can wear those at the same time that you're wearing our medical grade device to get a baseline.
From this research we found that the patients who had mild cognitive impairment or Alzheimer's, and now we've added patients with Parkinson's, dementia to the group, what they all had in common was they
there was a rat study in 2015 that showed that the rats anesthetized on their back did a poor job of moving these toxic neuro proteins during sleep, and we've just been the first ones to discover this in humans.
It's during slow wave sleep that the beta amyloid is cleared from the brain
That's what our device will quantify, "How many awakenings per hour do you have?
Back when the first study came out we said that 2% of women and 4% of men has sleep apnea, those numbers are now
I've historically recommended people might want to say what you can call a neurological dentist, someone who's looking at the impact of the teeth on the nervous system.
I'll give a shoutout to Dwight Jennings in the Bay Area in Alameda, who did the work for me
if you're getting treated for bruxism, and you have undiagnosed sleep apnea, wearing your bruxing device can actually make your sleep apnea worse.
I'd like to just add to it is that home sleep apnea tests are now only $200, $300.
I think it depends. If somebody sleeps on their stomach, if they sleep prone, you generally need a firmer mattress, if you sleep your side you need a softer mattress
Frank Lipman 519 Sleep Hacking
That's a concept that was ingrained in me from my Chinese medicine teachers Efrem Korngold and Harriet Beinfield in San Francisco
Dave Asprey A lot of people don't know that that kind of exposure to sunlight increases the thickness of the collagen in your skin, and it reduces your incidence of nearsightedness which is why we both talk about that in our work
Now, that we're seeing people with this mast cell stuff, some people do well on a low histamine diet, but those tend to be temporary problems. Once you correct the microbiome, once you correct the underlying parasite or Lyme or whatever it is, they become less mast cell reactive.
The concept of fascia I sort of got from yoga. But the idea that this soft tissue tightens around not only your organs but muscles, and you develop scar tissue and thickening, and its squeezes vessels, it squeezes lymphatics, it squeezes nerves. I think the idea for me of movement is not only moving and doing your resistance training and stretching but releasing that tight fascia.
A foam roller is something really important to have and going for bodywork, if you can. But keeping that fascia limber and letting your muscles and your joints move freely is really important in terms of movement.
Dave: I like to take a foam roller and put it on the Bulletproof Vibe, the whole body vibration plate we make. I'm rolling and thirty times a second, it's massaging, or using one ... There's actually vibrating foam rollers now.
Big time. I think the whole idea of the meridians running through the fascia, not universally accepted but fairly well accepted. Even from a Chinese medicine perspective and energy, you need to release the fascial planes to let energy move freely.
Dave: I would say there's really good evidence that fascia carries electrons at this point.
Dave: It's how your body stores hydration. If you have good collagen in your fascia, which is what it's made out of, you can carry a current better. It appears from the world of acupuncture that there's information, or there's something going through there, because we can modify it with needles, and we can measure changes in resistance where the meridians are.
Frank: I just see ... It's just one ... Why stress it? It's one of those areas not really stressed by even the holistic doctors or the functional medicine doctors. It's that one area that they've forgotten about, the whole fascial system.
Dave: A recent study came out that blew me away. It was some physicians who had figured out a technique of microscopy to look at tissues in the body while they were still attached to the body. They looked at the fascial planes, and they found that when they weren't dead that there were actually channels inside your fascia that carry fluid that are completely invisible when you take the collagen out, and you look at it all flattened out on a microscope. They found there was a pulsation through there. Apparently, there's this whole system in our fascia that no one ever noticed until now, except for maybe yogis or massage therapists or something, because they could look at the effects of it. But there's stuff going in there that I don't think anybody knows enough about.
Dave: I read a book maybe fifteen years ago by a surgeon, I think he was Johns Hopkins, but it might have been Harvard or somewhere. He was a Western guy, and he renamed himself to Dharma Singh Khalsa, and the book was called Meditation is Medicine.
James Maskell 357 Pharma to Functional Medicine
You said your doctor friends who go to these conferences. You have to pay $1000 to go to the conference. There's no content online at all about it, professional content. The companies who were delivering it are acting like it's the 1980s, so the first thing we did was just to put it all online for free so doctors could find out about it.
If you go to Silicon Valley and you ask people who are really smart, like Dan Kraft, who runs the Singularity University Futuremed, they point to a type of medicine as the future of chronic disease, which is called P4 medicine, and that was from Lee Hood, I think, came up with that idea.
It's personalized, it's preventive, it's participatory, and predictive, that's the fourth one. It's really looking at this sort of new era of medicine. Then you step back and you go, "Okay, well we need predictive, preventive, participatory medicine, personalized medicine, not medicine for the average human but for this human in front of me
That's why we decided to call our show the Functional Forum and really double down on functional medicine because it has that core operating system
In fact, that's the biggest problem, you call up a number, this guy took a course two years ago but he's still working his job in emergency room medicine because he couldn't work out how to build a practice, because at this moment in time the only way to practice functional medicine is to be an entrepreneur. There's no jobs. The Cleveland Clinic's hiring. Some practitioners have done a good job and have built a strong practice and they're hiring another physician, but there's no jobs going around. If the only doctors you can see are ones that just tend to be good at entrepreneurship, I'm not sure if you're going to get the cream of the crop.
One of the coolest ones that I think you'll get a kick of, these are one of our sponsors on the show, are called Iggbo, so they're Uber for phlebotomists so they're Uber for phlebotomists. Rather than having a phlebotomist in your office you can sound a little, basically like an Uber driver, who happens to be a phlebotomist, to your patient's house and they can do the blood draw at their home or office
Oh wow, if you left patients order their own labs then it's much more efficient, and people have their data, and people actually like doing that. You're now seeing it starting to move in that direction.
. If you multiply the numbers of doctors that commit suicide each year by their patient base, it's over a million people, and that's really scary, and there's a lot of suicide.
If you ask a group of functional medicine doctors, "Do you enjoy your work?" All hands go up
. There was this guy there who's from UCLA Stress Lab, and they've got this new world called Human Social Genomics, and this world has only been possible because now you can do genomic profiling every 3 months and see the changes in epigenetic expression. He says from their research that the biggest driver of all caused mortality is not nutrition, exercise, or smoking, it's relationships, it's the way that you interact with other people, it's social isolation, it's friendships, and connections.
Tom O'Bryan and Dan Moriarity # 247
Let me say something Dave, the class of herbs represented by adaptogens is very rare. Only 1 has been estimated in 10,000 beneficial plants that can actually fit the definition of adaptogens.
The first one, right off the bat, is that they're safe. They don't hurt anybody. They're non-toxic. What that means for all the listeners out there is that barring allergic reactions which anybody could be allergic to anything
The government, China, looked into it and they discovered that this is also known as gynostemma pentaphyllum and that's the actual botanical name. Now, ginseng has about 23 of these elements, phytonutrients called ginsenosides. The jiaogulan or gynostemma has over 80. It's incredibly powerful.
There's another one that I like quite a bit. It's called erythroxylum vacciniifolium. It is a South American herb. It's used in the Shamanic medicines down there.
Astragalus is the only, that I know of, natural substance that contains what they call cycloastragenol. Now, this is amazing because cycloastragenol has been shown in various studies which I invite any listeners to look that up to actually lengthen the telomeres
When you just talked about the extract of astragalus, that's one of the main active ingredients. It's something called TA-65 and we've had to guess. I'm going to talk about TA-65.
I'll give you some. More recent. Let's get away from Nikolai Lazarov and Israel Brekhman and their initial studies. Let's go flash forward to about 2008, 2009. Two scientists by the name of Panossian and Wikman who are well afforded on this subject, they looked at the way that adaptogens work.
Joseph Mercola 424 EMF
Dave Asprey: I will admit, I do have an Oculus Rift
I only use a speakerphone, not a wired headset. I use speakerphone and I put it three feet away from my body.
His name is Dr. Martin Pall, P-A-L-L. If you just type in his name and EMF on YouTube, you'll see many lectures he's given, and he'll go to it in far greater detail, maybe even explain it a lot better than I am, but I'm going to try to consolidate one of my talents, is to convert it to regular language
Dave Asprey: The EMFs are causing excess calcium
Dr. Mercola: Yes.
. I'm not hiding it from you, but the downstream causes the damage, but you have to understand that those voltage gated calcium channels, receptors, are seven million times more sensitive to EMF than the charge particles inside and outside the cell.
That means the safety standards are off by a factor of seven million. Seven million.
Essentially, you do not want to take a calcium channel blocker.
Once this voltage gated calcium receptor is activated or stimulated by the EMF, in less than five seconds, a million calcium ions will be streaming out of that receptor through that channel every second.
Once it's hit with the EMF, that calcium channel's going to flood in, so what does it do? It's going to stimulate the release from at the ... well, intracellularly of nitric oxide, and then when you have increased levels of nitric oxide, it's going to combine with super oxide, which is a free radical. Nitric oxide is also a free radical, many people don't know that. It's a beneficial free radical, which is why you want to be very, very careful taking high doses of antioxidants. Yes, antioxidants are good, but if you take too many, you can indiscriminately suppress beneficial free radicals that your
You need nitric oxide. It comes in, but it doesn't keep on coming in because the voltage gated calcium channels keep ... so it goes to extraordinary high levels, or it's managed higher than it's supposed to. Combined to the super oxide, and it forms a really dangerous free nitrogen radical, or free, not radical, free nitrogen species called peroxynitrate.
Patrick McKeown 434 Breathe less to do more with Oxygen
Sure, basically in the 1950s and 1960s there was a Russian doctor his name was Constantine, Dr. Constantine Buteyko and part of his research was working with astronauts during the Soviet space race
I want to look at breathing 24/7. So if somebody is doing the Wim Hof method, and they're taking big breaths over 30 breaths that's fine, but how are they breathing for the other 24 hours? That's where I come in.
There was an exercise to open up the nose, so I practiced it. It's basically breathe in, breathe out through your nose, pinch your nose, and gently hold your breath, and nod your head up and down for as long as you can. I was able to free my nose.
I have them slow down their breathing, really quieten their breath, really relax their breath, but I want them to slow down their breath to the point that they have air hunger. And to do that at various intervals throughout the flight. Now, what's happening there, I'm not sure, but it works, and I don't know how it's working. It's something amazing in the breath. You were talking about the Wim Hoff method. You were probably aware of the paper by Cox. They did a study. They had the control group and the experimental group. The experimental group did hyperventilation and strong breath-holds, and he induces a hypocapnic hypoxic response.
As you hold your breath there could be a buildup of heat inside the nasal cavity, and also a buildup of nitric oxide. So there could be any number of factors there, but literally I've used breath-holding to decongest noses in about 7,000 individuals. And it's a really, really wonderful and easy way to do it.
Yeah, just after a normal exhalation, pinch your nose and sway holding your breath. Keep holding your breath until you feel a relatively strong air shortage. So keep holding your breath until you feel a fairly strong air shortage. So what you're doing there is just changing blood gasses, and as you hold your breath nitric oxide is going to be released from the paranasal sinuses into the nasal cavity. When it gets pretty tough let go, but breath in through your nose. So when it gets pretty tough let go, and then calm your breathing. Always quieten your breathing at the end of it, but breath in and out through your nose. Now, if you try that six times
Sure, so the background is for decades scientists thought nitric oxide ... they found it very hard to believe that a gas that was so toxic outside the human body could actually be helpful within in, because it's responsible for pollution.
Now, it is produced in various sites in the body, but if you breathe through your nose the particles per billion are 50 times as breathing through your nose, and if you breathe through your mouth it's 10. Now, one of the major benefits, from a breathing point of view of nitric oxide, is we're sitting upright. Most concentration of blood is in the lower lobes of the lungs and nitric oxide, when you bring air through your nose and you breathe slowly, you carry a high concentration of nitric oxide into the lungs. And nitric oxide shifts the blood from the lower lobes of the lungs to the upper. So you get a better ventilation profusion. Also, if, for instance, we're breathing through the mouth we're activating, generally, the upper chest because mouth breathing is fast breathing, and fast breathing is only ventilating, more so, the upper lobes of the lungs rather than the lower. When you breathe through your nose you'll naturally activate the diaphragm, so we're all about deep breathing. Sometimes people say that we're talking about shallow breathing. No, we’re not.
Dave Asprey: That is absolutely true, and people talk about these alkaline diets and things like that, but the biggest thing that makes your tissues acidic would be carbon dioxide makes ..
Patrick McKeown: Well, carbonic would be the preferred, but the hydrogen iron would be the ... so basically it's carbon dioxide in the blood, it'll form ... sorry, you're right, carbonic acids. Then it dissociates it
there's a researcher called Ray Peat in Portland in Oregon, and he's looked at carbon dioxide for probably decades
The longer the breath-hold time, the better. It's a really good measurement.
Dave Asprey: But, unless I'm really sick or something I will never do that. But you've convinced me. I'm gonna go get some LipSeal tape
So number three things I'm saying is breathe through your nose, breath-holding is very helpful too, don't ... not necessarily breathe in and hold the breath, but breathe out and hold the breath
Dave Asprey: ... increased nitric oxide inside the cell
Dr. Mercola: Inside the cell, yes.
The study's a little more difficult and challenging to do in that, but it probably is a contribution, although, of course, your wife would know about that. She's been a fertility specialist. Regarding the brain, these voltage gated calcium channels also release neurotransmitters and neuroendocrine hormones.
We've got my device. I use a TES, TES-593, which is a microwave meter
Yeah. It will tell me where I'm going to sleep. Thank you, Elliot. We're going to take this out and turn it on. It looks like a there's a lot of different devices. Some of them are pretty expensive, like a few thousand dollars. This one retails for $500, but if you just go to Google Shopping, or even Amazon, you can find it for
... can find it for $350. A lot of people make the mistake, I mean Trifield's a very popular, but folks, please understand, Trifield meters only measure magnetic, and if you have a high magnetic exposure, as you do with from an inverter for several [inaudible] solar panels, that Faraday cage will not remediate against it because magnetic goes right through it.
The other sources I neglected to mention were, earlier, your wireless mouse, your wireless keyboard, anything that's wireless, including this ring. The OURA Ring, which you and I are both fans of. If you have an OURA Ring, I know many of you do, it has to be in airplane mode. The problem, and it's a serious problem, and if you could please write the company, we need as much pressure on them as possible to fix the bug because this will spontaneously come out of airplane mode on a regular basis, multiple times during the day. It's unacceptable because it is a significant exposure.
Dave Asprey: Take more magnesium, you heard it here first.
Dr. Mercola: Yeah. We all know that 80% of us, the population, maybe is in deficient, so that's not a bad idea from [inaudible].
Dave Asprey: I do 800 milligrams a day now.
Dr. Mercola: I think you're going to want to increase it closer to two grams.
Yeah. Clearly magnesium, and we're looking at something called magnesium bicarbonate, which you can't buy, but you have to create in some exotic strategies, or maybe do it through another process. We're in the process of identifying grass, generally recognized as safe supplements that can be used and can be purchased without having to do some of these crazy biohacks.
You want to put it in a little bottle, preferably with a cap, so because it's hydrogen gas, it's going to blow out, so you put it in there, not cold water because it'll slow down the reaction time, and you put it in and let the tablet dissolve completely, and then you open the cap and drink it as quickly as you can without swallowing it the wrong way.
I don't recommend hydrogen water
Yeah. I don't recommend people taking vitamin C regularly. I think it's something, especially Liposomal C, that everyone should have in their emergency kit because I've never seen anything more effective. Taking four grams every hour, Liposomal C, because you will not get loose stools
Dave Asprey: Yeah, it doesn't raise the levels nearly as much, though.
Dr. Mercola: I think it may raise them more.
Dave Asprey: Wow. I'd be interested to see that research.
Dr. Mercola: Yeah. I think Tom Lebee's done it
Because it goes intracellular where you need it.
Dan Pompa 484 Generational Toxicity
Her estrogen metabolized, one of which is very, very toxic, called 4-Hydroxyestrone, which was through the roof. That is known to be linked to cancer, especially breast cancer
On every cell, there's the receptors to hormones, whether it's thyroid hormone, leptin, insulin, testosterone, estrogen. The hormones need to attach to these receptors to get their message in the cell so you feel good and normal.
Toxins make their way in and around these cells and the membranes because they're fat, so it pulls in the toxins. It blunts these receptors. It drives inflammation of the cell, which blunts the receptors.
So doctors are giving T4, which is an inactive thyroid hormone, it needs to be converted into T3, which is active, which connects to those receptors on the cell. In that conversion, most of it happens in the liver. Toxins affect the liver and now you're not making the conversion. Here's the frustrating point. Your blood work can look normal because you're not converting
Look, people are doing more and more colon cleanses, far-infrared saunas, the 10-day herbal cleanse, I don't have a problem with any of these things, but unless you get up to the cell, you're not going to get well. That's where real detox is
Dave: But other things like bentonite clay and even cholestyramine, which is a prescription drug, because as your cells are detoxing, you don't want it to be reabsorbed through the colon
Dan: Exactly. So, I took that work. I said, "I don't want to ingest or have my clients or patients ingesting resin," because as you know, cholestyramine, what he was using, worked great, but one of its side effects was severe constipation
My R number two is regenerate the cell membrane. Regenerating the cell membrane, really, which is ... I feel like scientists understand this, or guys like you more so than treating doctors. The key to detox really is this membrane. The membrane allows the good stuff and the bad stuff out.
Look, it's an epidemic of people with low energy, and if you have low cellular energy, you're not going to detox right. That mitochondrial membrane is vital to the process of making ATP cell energy and detox. Then the endoplasmic reticulum, that's where you fold proteins. You are not a healthy human
Omega 6 gets a bad rep. Omega 6, as it turns out, just so happens to be one of the key fats of fixing the membrane. Here's the problem. It's the key fat to fixing the membrane but we're getting all adulterated Omega 6 and everything, vegetable oils, canola oils, everything, the corn oils. I believe it's more important than even the Omega 3 as far as fixing this membrane because we're all getting adulterated Omega 6
Look, I believe that you're right in the sense that we're bombarded with adulterated Omega 6 in everything that we're eating. I mean, even your roasted nuts
We know that. 102 days of dysfunction, meaning it integrates into your membranes, and it takes about 102 days for basically your membranes to do the right thing. It's damaged for 102 days. I just read a recent study. It's probably more like four and a half months, so maybe a better put would be 132 days of dysfunction, when you're exposed to these bad oils,
My R number three, by the way, is restoring cell energy. And that's the mitochondria. And that mitochondrial membrane is more fragile than the outer membrane of the cell.
R number five, just to skip so I could prove my point, is re-establishing methylation. Look, all of these cell functions are critical for detox. Fat affects every one of them directly or indirectly, so very, very important subject, and most people don't understand.
One is called CytoDetox. It has the ability to penetrate some of these cell membranes. I love DMSA
It's a binder. It no doubt holds on and doesn't let go, but that's only part of the detox. We upregulate cell function, or we used a real binder, but we'd also ... I love DMSA as a binder but I don't like the injectable. Here's why. Whether it's DMSA, DMPS, or EDTA, you mentioned a couple of those, those are real chelators, which is ... No doubt they work. They hold on, they grab hard, but typically they're used incorrectly. If you do an IV, for example, of say DMPS or EDTA, it goes in, it grabs, and it goes away and pulls a lot out at once. The problem is it sets up a concentration gradient. The body keeps releasing metal and people can get very sick. They don't typically get sick from the agent, they get sick from the redistribution of metals. Therefore, if you take them underneath their half-life in the body, you can minimize a lot of that problem.
So DMPS, for example, you have to take it every eight hours to minimize that and take it for at least three days, so when we use that as a group of doctors, we use it within its half-life and we use it correctly, in this whole system by the way that I'm talking about, using binders in the gut, upregulating cell function. The DMPS can be used to help these things move out of the body. DMSA has to be taken every four hours.
Dave: This is basically Andy Cutler's protocols you're talking about. Dan: Andy Cutler was right, exactly. He didn't do it within this whole system that we do, but at least he used the binders correctly
Then you have Chlorella, which it binds but it's not a really strong binder. It can create redistribution. I would put Cilantro in that category as well
They get their carbohydrate cravings. Listen to that. So they did, and the feedback was actually tremendous. With my group of doctors, I said, "Try this. You have your low carb group. Try one week before their period. Put them on a high healthy carbohydrate diet." Eat more yams, sweet potatoes, or berries, et cetera. Sure enough, magic happens. So we do that even weekly oftentimes
You have to understand. What happens is if you get chronically low insulin for a long period of time, you need insulin to make hormone conversions from T4 to T3, right? That's thyroid hormone, you used that example. T4 to T3, the active form is T3, insulin plays a role in that conversion. When insulin gets very low and you have high heavy metals, you're not making that conversion, so having those
Barry Sears 300
f they’re taken in therapeutic levels, can activate our genes. Particularly there are 3 different types of gene classes they activate. At lower levels they activate anti-oxidative genes. These are the genes that cause a transcription of enzymes, antioxidant enzymes like superoxide dismutase and glutathione peroxidas
At still higher levels these polyphenols now activate anti-inflammatory genes, especially with those that basically inhibit the activation of nuclear factor kappa B, the master gene that turns on inflammation. At still higher levels they activate the anti-aging gene SIRT1 that makes the enzyme AMPKinase thus a key to controlling our metabolism.
These are the ones you find primarily in berries. But then you have a problem. Berries are also rich in sugars. So you have between a rock and a hard place. That’s why concentrates, concentrates of polyphenol sources, which have been now stripped out of non-biologically active materials and stripped out of carbohydrates, become a very, very excellent source to maintain the levels of these key ingredients we have to have on really a daily basis.
calories were coming into the mouth and being trapped in your fat cells and not being released to make energy so just ATP. Literally you are basically gaining weight but you are starving at the same time.
Dave brain octane oil which is a purified, it’s one of the 4 kinds of MCTs that raises ketones. Usually within a half hour you can get your blood ketones up enough to suppress ghrelin and to turn on CCK. These are hunger hormones for people listening who aren’t biochemist nerds
Dave: How do they wipe out glycogen? I wasn’t aware of that. Barry: Because again to burn the fatty acids, because these short chain fatty acids are also very effective surfactants. They dissolve membranes.
But, and studies at Harvard Medical School have shown this, if you maintain a ketogenic diet what occurs after about an adaptation after 1 or 2 months is that you start to increase the levels of cortisol.
ATP is interesting because any cell in the body will only store about 10 seconds worth of ATP. You have to make it on demand and you don’t know when that demand is going to be.
Asprey I take grape skin polyphenols, grape seed extract, I take resveratrol, trans resveratrol, pterolstilbene, and a handful of other polyphenol substances in my normal daily stack of things
The medium chain triglycerides are relatively water soluble. They enter into the blood stream through the portal vein. They go directly to the liver and they’re metabolized there on the spot. But to do so they wipe out all the storage of glycogen. That’s where you get in ketosis very quickly. But now you have no reserve levels to basically maintain blood sugar levels for the brain, the only organ that can basically use energy.
Because again to burn the fatty acids, because these short chain fatty acids are also very effective surfactants. They dissolve membranes.
Now that’s okay. You’ll get the 5 hours. No question about that. But, and studies at Harvard Medical School have shown this, if you maintain a ketogenic diet what occurs after about an adaptation after 1 or 2 months is that you start to increase the levels of cortisol.
That’s my definition is the maximum conversion of dietary calories to ATP. Then you have a system you can follow for lifetime.
Again, we’ve gone over the years, we’ve always used really a 2 to 1 ratio of EPA to DHA. The reason why I always like both because they do different things. The EPA is more anti-inflammatory than the DHA. DHA has structural properties that make it very unique compared to the EPA and both at high levels can make another group of hormones called resolvents which are really the holy grail of medicine.
… DHA but of arachidonic acid to EPA. That’s the marker of inflammation. Your goal is to keep up between 1.5 and 3. Because that’s a sweet spot of controlling inflammation. For example, the average American is 18, which explains why our healthcare cost is so high.
But that’s really the ratio of arachidonic acid, which is the precursor of the hormones, the direct precursor, and EPA, the direct precursor of the anti-inflammatory hormones.
we now know one of the problems was called metabolic endotoxemia. That basically very small fragments of bacteria, just gram-negative bacteria, if we have even the trace amounts of a leaky gut can get into the blood,
I do like the conjugated linoleic acid. It’s a very interesting one because it’s a very specific stereoisomer in butter, unlike the stuff you buy in a health food store which actually causes insulin resistance.
From that standpoint butter is a very good way of concentrating the natural and most beneficial form of the isomer of conjugated linoleic acid.
Now stearic acid I actually like because stearic acid once it’s absorbed is rapidly desaturated into oleic acid. That’s why stearic acid is the only saturated fat that will not raise cholesterol.
Now palmitic acid it’s almost the same. It’s about the same, it’s almost totally different. Palmitic acid is a very, very powerful pro-inflammatory saturated fat. On the scale of 1 to 10 I give it a 15, because it can interact with specific receptors in cells and the same receptors that basically recognize the fragments of the gram-negative bacteria, lipopolysaccharides, they basically recognize the palmitic acid
Gary Volino, Gary Ryan 401 Exercise and Pulsed Electromagnetic Fields
What happened to me was I hurt my back and I went to a chiropractor and he happened to have one of these machines by Pulse Centers. It worked wonders for the pain in my back so I was very curious in what it did. Just so happened it was made out of Atlanta, Georgia. I live in Atlanta, Georgia, so I started
The Earth is a huge generator of electromagnetic fields, so I think it's important to realize what we're doing is the good side of electromagnetic fields. We're simulating that electromagnetic field that comes from the Earth. That pulsing, it's called the Schumann Resonance as a matter of fact, that Schumann Resonance happens 7.8 times a second.
You have plenty of scientists, Ph.Ds, Harold Bird, Jerry Tenant that have studied this and reported the effects of these low frequencies high intensities. Steven Beebe, as a matter of fact, from Old Dominion University wrote an excellent paper around short bursts of energy entering the body through electromagnetic fields
ave: So globally, there's practitioners who have these and you have finder, I'm guessing on your website?
Gary Volino: There's a locator on our website.
Dave Asprey but I also expose myself pretty much every night I do at least a few minutes on the Pulse Center's equipment that I've got here which is the Big Pulse XL Pro.
Nasha Winters 528
One of the things you started the talk off today with the elephant story and you talked about the TP53 gene. Okay. This little guy is damaged in about 50% of the population, meaning it's not behaving as the best gatekeeper of our genes
To come back around to the ACE score, the adverse childhood events, it's just a simple questionnaire, 10 questions about particular experiences had before the age of 18 that we know changes epigenetic expression and causes things like breakdown of our TP53 function
EMDR is a very powerful one. For people listening who haven't heard of it, eye movement dissociative response and this is a thing you do with a therapist. They move your eyes back and forth, put your brain in trauma reset mode, and you can let go of stuff.
You mentioned something pretty powerful in there, something that I'm a huge fan of and early supporter of and that's ketosis. I've noticed that when I have ketones present, even just low level ones, my ability to meditate, to do healing work on myself is much better.
t, basically me pulling it out of my ass in 2000, 2001 because there was no Miriam Kalamians or Thomas Seyfrieds or Travis Christoffersons in the world to guide us on this
Dr. Adrienne Scheck's work are able to now show that ketones impact all 10 of the 10 hallmarks of cancer.
Yes, that piece, and for me, it took two decades, so there you go. Number one, sustained proliferation of cells. Hello. There was that TP53 conversation we had in the beginning. You don't have something to turn that off. One of the things we noticed is that ketones upregulate TP53 activity in the way we want it to. Number two, insensitivity to antigrowth signals, so they become like little rogue toddlers who just ignore anybody telling them to put their shoes on. They just ignore you, forget any signals coming their way, and they just do their own thing. That's a hallmark. Another hallmark is the evasion of apoptosis. Now, that comes directly down to the mitochondria. The mitochondria are in charge of apoptosis.
Anthroposophical medicine, which was built on the philosophy by Rudolf Steiner in the early 1900s with this concept of looking at the world around you in deep observation and starting to see how the outside world reflected to the inside
He somehow knew to take a little bit of those, put them basically in a centrifuge and grow them, then create an extract and then inject it. This started happening in 1917 with the work of an oncologist, [Dr. Eda Vegman 01:02:02], of that time and now a hundred years later, it is the most studied integrative oncology therapy in the world. It's over 2500 studies, over 250 that we would call good per Western medical standards. There's a clinical trial that I helped get the IRB going and still consult on a lot at Hopkins that started in February 2017. We are, knock on wood, looking at four more starting in this country within the next 16 to 18 months. It has one of the most profound ways to stimulate a low grade fever, so it has ways to stimulate natural killer cells, natural T cells, dendritic cells.
Kris Smith 483 Keto and Cancer
Dan Sullivan 485 Thinking about thinking
Yeah, well, I tell you, so I'd been in the APEX program, which is Jeff Gladden, since the middle of the year before, so this was '16.
Yeah, the Vasper has been great. I'm into my fourth year of the Vasper, so this is a man by the name of Peter Wasowski, engineer, inventor. He created an exercise device that puts together interval training, compression, so your muscles get compressed, and then cooled, so it's roughly about 43 degrees. You put on what look like blood pressure cuffs on your upper arms, upper legs, and you do 20 minutes. The moment you start the exercise, it gets flooded with cold water, so the cuffs are not filled with air. They're filled with cold water, and the moment you start exercising, you get a muscle burn as if you've been exercising intensely for an hour or two hours, and your brain is being fooled that there's muscle tear, and it starts flooding your system with growth hormone and testosterone and IGF-1 and other things.